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Stem cell leukemia

MedGen UID:
237186
•Concept ID:
C1378511
•
Neoplastic Process
Synonym: Undifferentiated leukemia
SNOMED CT: Stem cell leukemia (24072005); Undifferentiated leukemia (24072005)

Professional guidelines

PubMed

Management of chemotherapy-induced thrombocytopenia: guidance from the ISTH Subcommittee on Hemostasis and Malignancy.
Soff G, Leader A, Al-Samkari H, Falanga A, Maraveyas A, Sanfilippo K, Wang TF, Zwicker J
J Thromb Haemost 2024 Jan;22(1):53-60. Epub 2023 Oct 11 doi: 10.1016/j.jtha.2023.09.031. PMID: 37827380
Future Directions in Chronic Phase CML Treatment.
Javidi-Sharifi N, Hobbs G
Curr Hematol Malig Rep 2021 Dec;16(6):500-508. Epub 2021 Oct 14 doi: 10.1007/s11899-021-00658-w. PMID: 34648120
How we use venetoclax with hypomethylating agents for the treatment of newly diagnosed patients with acute myeloid leukemia.
Jonas BA, Pollyea DA
Leukemia 2019 Dec;33(12):2795-2804. Epub 2019 Oct 18 doi: 10.1038/s41375-019-0612-8. PMID: 31628431

Recent clinical studies

Etiology

Immune-related gene signature predicts clinical outcomes and immunotherapy response in acute myeloid leukemia.
Xu Q, Cao D, Fang B, Yan S, Hu Y, Guo T
Cancer Med 2022 Sep;11(17):3364-3380. Epub 2022 Mar 30 doi: 10.1002/cam4.4687. PMID: 35355427Free PMC Article
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Montefiori LE, Bendig S, Gu Z, Chen X, Pölönen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG
Cancer Discov 2021 Nov;11(11):2846-2867. Epub 2021 Jun 8 doi: 10.1158/2159-8290.CD-21-0145. PMID: 34103329Free PMC Article
Oncogenes in myeloproliferative disorders.
Tefferi A, Gilliland DG
Cell Cycle 2007 Mar 1;6(5):550-66. Epub 2007 Mar 24 doi: 10.4161/cc.6.5.3919. PMID: 17351342
T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination.
Nagano M, Kimura N, Akiyoshi T, Nishimura J, Kozuru M, Okamura J, Katsuno M, Yoshida T, Takeshita M, Tachibana K, Ohshima K, Kikuchi M
Leuk Res 1997 Aug;21(8):763-73. doi: 10.1016/s0145-2126(97)00025-8. PMID: 9379684
GATA-1, GATA-2, and stem cell leukemia gene expression in acute myeloid leukemia.
Shimamoto T, Ohyashiki JH, Ohyashiki K, Kawakubo K, Kimura N, Nakazawa S, Toyama K
Leukemia 1994 Jul;8(7):1176-80. PMID: 8035609

Diagnosis

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.
Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A
Leukemia 2023 Apr;37(4):751-764. Epub 2023 Jan 31 doi: 10.1038/s41375-023-01833-z. PMID: 36720973
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Montefiori LE, Bendig S, Gu Z, Chen X, Pölönen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG
Cancer Discov 2021 Nov;11(11):2846-2867. Epub 2021 Jun 8 doi: 10.1158/2159-8290.CD-21-0145. PMID: 34103329Free PMC Article
The Dual Role of ROS in Hematological Malignancies: Stem Cell Protection and Cancer Cell Metastasis.
Samimi A, Khodayar MJ, Alidadi H, Khodadi E
Stem Cell Rev Rep 2020 Apr;16(2):262-275. doi: 10.1007/s12015-019-09949-5. PMID: 31912368
Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists.
Zhao Y, Wu K, Wu Y, Melendez E, Smbatyan G, Massiello D, Kahn M
Curr Mol Pharmacol 2018;11(2):113-121. doi: 10.2174/1874467210666170919155739. PMID: 28933312
T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination.
Nagano M, Kimura N, Akiyoshi T, Nishimura J, Kozuru M, Okamura J, Katsuno M, Yoshida T, Takeshita M, Tachibana K, Ohshima K, Kikuchi M
Leuk Res 1997 Aug;21(8):763-73. doi: 10.1016/s0145-2126(97)00025-8. PMID: 9379684

Therapy

Unifying targeted therapy for leukemia in the era of PARP inhibition.
Boila LD, Sengupta A
Exp Hematol 2023 Aug;124:1-14. Epub 2023 May 24 doi: 10.1016/j.exphem.2023.05.005. PMID: 37236341
KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.
Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A
Leukemia 2023 Apr;37(4):751-764. Epub 2023 Jan 31 doi: 10.1038/s41375-023-01833-z. PMID: 36720973
Immune-related gene signature predicts clinical outcomes and immunotherapy response in acute myeloid leukemia.
Xu Q, Cao D, Fang B, Yan S, Hu Y, Guo T
Cancer Med 2022 Sep;11(17):3364-3380. Epub 2022 Mar 30 doi: 10.1002/cam4.4687. PMID: 35355427Free PMC Article
Evolving insights on histone methylome regulation in human acute myeloid leukemia pathogenesis and targeted therapy.
Boila LD, Sengupta A
Exp Hematol 2020 Dec;92:19-31. Epub 2020 Sep 17 doi: 10.1016/j.exphem.2020.09.189. PMID: 32950598
Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities.
Ren M, Qin H, Ren R, Cowell JK
Leukemia 2013 Jan;27(1):32-40. Epub 2012 Jul 11 doi: 10.1038/leu.2012.188. PMID: 22781593Free PMC Article

Prognosis

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.
Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A
Leukemia 2023 Apr;37(4):751-764. Epub 2023 Jan 31 doi: 10.1038/s41375-023-01833-z. PMID: 36720973
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.
Cai B, Liu Y, Chong Y, Mori SF, Matsunaga A, Zhang H, Fang X, Chang CS, Cowell JK, Hu T
Mol Cancer 2022 Jul 29;21(1):156. doi: 10.1186/s12943-022-01628-3. PMID: 35906694Free PMC Article
Immune-related gene signature predicts clinical outcomes and immunotherapy response in acute myeloid leukemia.
Xu Q, Cao D, Fang B, Yan S, Hu Y, Guo T
Cancer Med 2022 Sep;11(17):3364-3380. Epub 2022 Mar 30 doi: 10.1002/cam4.4687. PMID: 35355427Free PMC Article
CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement.
Yoshida T, Kimura N, Sawada H, Suematsu E, Nagano M, Akiyoshi T, Motomura S, Kikuchi M, Nishimura J, Tamura K
Intern Med 1999 Jul;38(7):547-55. PMID: 10435360
Biological characteristics of CD7(+) acute leukemia.
Miwa H, Nakase K, Kita K
Leuk Lymphoma 1996 Apr;21(3-4):239-44. PMID: 8726405

Clinical prediction guides

A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.
Cai B, Liu Y, Chong Y, Mori SF, Matsunaga A, Zhang H, Fang X, Chang CS, Cowell JK, Hu T
Mol Cancer 2022 Jul 29;21(1):156. doi: 10.1186/s12943-022-01628-3. PMID: 35906694Free PMC Article
Immune-related gene signature predicts clinical outcomes and immunotherapy response in acute myeloid leukemia.
Xu Q, Cao D, Fang B, Yan S, Hu Y, Guo T
Cancer Med 2022 Sep;11(17):3364-3380. Epub 2022 Mar 30 doi: 10.1002/cam4.4687. PMID: 35355427Free PMC Article
Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.
Curtis DJ, Salmon JM, Pimanda JE
Stem Cells 2012 Jun;30(6):1053-8. doi: 10.1002/stem.1093. PMID: 22593015
Kidney, blood, and endothelium: developmental expression of stem cell leukemia during nephrogenesis.
Dekel B, Hochman E, Sanchez MJ, Maharshak N, Amariglio N, Green AR, Izraeli S
Kidney Int 2004 Apr;65(4):1162-9. doi: 10.1111/j.1523-1755.2004.00489.x. PMID: 15086455
The role of the stem cell leukemia (SCL) gene in hematopoietic and endothelial lineage specification.
Bloor AJ, Sánchez MJ, Green AR, Göttgens B
J Hematother Stem Cell Res 2002 Apr;11(2):195-206. doi: 10.1089/152581602753658402. PMID: 11983093

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